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PETHIDINE buy in Johor Bahru
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    PETHIDINE buy in Johor Bahru
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    PETHIDINE buy in Johor Bahru
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    PETHIDINE

    PETHIDINE

    ID: 8317: 65982
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    Malaysia, Johor Bahru
    Technical characteristics
    • Brandpethidine hcl
    Description

    Mechanism of Action

    Pethidine (Meperidine) is a synthetic opioid which primarily acts on m opioid receptors. It mainly acts on the CNS and respiratory and GIT systems. The drug is well absorbed orally but more than 50% undergoes first pass metabolism. Peak analgesic effect occurs in 1-2 hours. Rate of absorption may be erratic after I.M. injection, analgesic effect starts within 10 minutes and peaks by 1 hour. Duration of effective analgesia is about 1.5-3 hours

     

    Indications

    Pethidine is primarily used for analgesia in anaesthetic medication. It may be used during labour for analgesia. It is not the drug of choice for treatment of severe prolonged pain because of short duration of action and higher CNS toxicity

     

    Dosage

    Adults : 50-100mg I.M. Inj., rarely it is given : 25-50mg I.V. Inj. slowly

    Children : 1-2mg/kg I.M. Inj.

     

    Contraindications

    COPD and cor-pulmonale,   head injury specialy with doubt of intracranial bleeding. History of convulsions in past

     

    Special Precaution

    Use with caution in infants, elderly, in patients with hepatic or renal insuficiency, compromised respiratory function, decreased blood volume and abdominal pain

     

    Adverse Drug Reactions

    Nausea and vomiting. Constipation, urinary retention, miosis though less than morphine. Over dosage causes hallucinations, tremors, mydriasis, delirium and convulsions. Tolerance and dependence may occur. Repeated I.M. Inj. can cause local irritation and fibrosis

     

    Status in

    1. Pregnancy  : Use with caution

     

    Interactions

    Tricylic antidepresants, chlorpromazine, : Enhance respiratory depression; MAOIs : They interfere with metabolism of pethidine and lead to increase risk of CNS excitation with delirium, hyperthermia, headache, convulsions and coma

     

    Preparations of PETHIDINE

     

    Pharmaceutical Company

    Brand Name

     

    HaffKine

     

    PETHIDINE HCL   

    • Vial Inj              50mg/ml
    • Vial Inj          100mg/2ml      

    Neon Labs

     

    PETHIDINE INJ 

    • Vial Inj             50mg/ml 
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